D. Kiesewetter, B. Costa
Jul 1, 1993
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0
Influential Citations
14
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The radiochemical synthesis of the high affinity, selective sigma receptor ligand, N1-3-[18F]Fluoropropyl-N4-2-([3,4-dichlorophenyl]ethyl)piperazine, is reported. The labeled compound is prepared by fluoride displacement on a bismethanesulfonate salt of the propyl methanesulfonyloxy precursor. The product is isolated by first passage through a BONDELUT-SI and subsequently HPLC in high radiochemical and chemical purity with a decay corrected radiochemical yield of 49 ± 9%.