T. Kogan, T. Rawson
Nov 17, 1992
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The syntheses of (2 S , 6 R )-, and (2 S , 6 S )-3-oxo-6-[(phenylmethoxy)carbonyl]-2,-piperazineacetic acid methyl esters from L - or D -serine and dimethyl- D -malate are described. Acylation of the (2 S , 6 S ) isomer with 3-methoxyphenylacetyl chloride, hydrogenolysis of the benzyl ester, followed by treatment with oxalyl chloride then aluminum chloride led to an unexpected tricyclic product into which a C 2 O 2 unit had been incorporated.