Wen-bin Yang, S. Patil, Cheng-Hsin Tsai
Jan 7, 2002
Citations
0
Influential Citations
20
Citations
Journal
Tetrahedron
Abstract
Abstract l -Gulose, an essential component for the antibiotic and antitumor activities of bleomycin A2, was synthesized in 47% yield from d -glucono-1,5-lactone. The effective cleavage of acetonides by SnCl2 in the presence of tert-butyldimethylsilyl ethers was of importance in the course of synthesis. Elaboration of d -glucono-1,5-lactone that includes a step of oxidative degradation by Dess–Martin periodinane also afforded a respectable yield of l -xylose.