Anjan Ghatak, J. Dorsey, C. Garner
May 19, 2003
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihydroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest.