Takuji Magata, S. Nagano, T. Endo
Sep 13, 2017
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Journal
Tetrahedron Letters
Abstract
Abstract Methyl 2-[1-[(tert-butoxycarbonyl)amino]ethyl]-4-methyloxazole-5-carboxylate (1) was synthesized with high optical purity via a Pd–catalyzed amide coupling with vinyl triflate with subsequent oxazole formation. The latter reaction proceeds via bromination of an enamide with NBS and DBU-promoted cyclization. The oxazole subunit positional isomer in a macrocyclic azole peptide was obtained in a good yield without racemization. The scope and limitations of this reaction were also investigated.