Miki Monoi, S. Hara
Aug 1, 2012
Citations
0
Influential Citations
9
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Methyl-3,5,7-trifluoroadamantane-1-carboxylate, a key intermediate for the synthesis of 1-amino-3,5,7-trifluoroadamantane (trifluoroamantadine), was synthesized by the electrochemical fluorination of methyl adamantane-1-caroxylate in pyridine–5HF under constant current conditions. After the reaction, the product was extracted from pyridine–5HF by hexane–CH 2 Cl 2 , and recovered pyridine–5HF was used repeatedly.