Paper
An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction.
Published Nov 30, 2001 · Young Bae Kim, Eun Hee Choi, G. Keum
Organic letters
Q1 SJR score
56
Citations
0
Influential Citations
Abstract
A new one-pot procedure for the efficient synthesis of novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer as a bifunctional component with various alpha-amino acids and isocyanides by the Ugi five-center three-component reaction (U-5C-3CR) was developed. [reaction: see text]
Study Snapshot
This one-pot procedure efficiently synthesizes novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer and various alpha-amino acids and isocyanides in the Ugi multicomponent reaction.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Formation of 1,1'-iminodicarboxylic acid derivatives, 2,6-diketo-piperazine and dibenzodiazocine-2,6-dione by variations of multicomponent reactions.
Multicomponent reactions can efficiently synthesize complex structures like 1,1'-iminodicarboxylic acid derivatives, 2,6-diketo-piperazine, and dibenzodiazocine-2,6-dione in one-pot reactions.
2001·23citations·I. Ugi et al.·Chemosphere
Chemosphere
Multicomponent Reactions with Isocyanides.
Multicomponent reactions with isocyanides are popular in the pharmaceutical industry for preparing large compound libraries and offering new opportunities for natural product synthesis.
2000·3156citations·A. Dömling et al.·Angewandte Chemie
Angewandte Chemie
Maximizing synthetic efficiency: multi-component transformations lead the way
Multi-component transformations, such as Ugi four-component condensation, have become efficient and cost-effective tools for combinatorial and parallel synthesis, enabling high-throughput screening in pharmaceutical research.
2000·869citations·H. Bienaymé et al.·Chemistry
Chemistry
Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.
Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis facilitates efficient synthesis of structurally complex compounds and can be integrated with ones providing structurally diverse compounds.
2000·201citations·Daesung Lee et al.·Organic letters
Organic letters
Applications of N-BOC-diamines for the solution phase synthesis of ketopiperazine libraries utilizing a Ugi/De-BOC/Cyclization (UDC) strategy
This study demonstrates a novel method for solution phase synthesis of ketopiperazine libraries using mono N-BOC diamines in the Ugi multi-component reaction, leading to novel routes to dihydroquinoxalinones and 1,4-benzodiazepines.
1998·49citations·C. Hulme et al.·Tetrahedron Letters
Tetrahedron Letters
SYNTHESIS OF RIGID HYDROPHOBIC TETRAZOLES USING AN UGI MULTI-COMPONENT HETEROCYCLIC CONDENSATION
This study demonstrates a highly convergent four-component, two-step, one-pot reaction for synthesizing rigid hydrophobic tetrazoles, enabling the preparation of various small organic "drug-like" molecules.
1998·54citations·H. Bienaymé et al.·Tetrahedron Letters
Tetrahedron Letters
Multi-component reactions 13: Synthesis of γ-lactams as part of a multiring system via Ugi-4-centre-3-component reaction
This study demonstrates a one-pot Ugi-4-centre-3-component reaction for synthesizing -lactams in a multiring system, using C-protected amino acids as amine components.
1998·62citations·Cordelia Hanusch-Kompa et al.·Tetrahedron Letters
Tetrahedron Letters
Citations
Access to 2-arylquinazolines via catabolism/reconstruction of amino acids with the insertion of dimethyl sulfoxide.
This study demonstrates the first-ever synthesized 2-arylquinazolines by catabolism/reconstruction of amino acids with the insertion of dimethyl sulfoxide, offering a new method for studying amino acid conversion.
2021·2citations·Jin-Tian Ma et al.·Chemical communications
Chemical communications
Design, synthesis and antibacterial activity evaluation of novel 2‐(4‐(( 1‐aryl‐1 H ‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)2‐(2‐oxoazetidin‐1‐yl)acetamide derivatives
Novel 2(4((1aryl1 H 1,2,3triazol4yl)methoxy)phenyl)2(2oxoazetidin1yl)acetamide derivatives) show very good antibacterial activity,
2020·3citations·S. Zarei et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors
Artificial polyphenols synthesized using the Ugi multicomponent reaction show potential as inhibitors of -amyloid protein aggregation, with a lead selected for inhibition of truncated protein ApE3-42.
2019·10citations·D. Galante et al.·Molecules
Molecules
α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications
The Ugi four-component reaction (U-4CR) with -amino acids offers a powerful tool for synthesis of drug-like multi-functionalized scaffolds in a single step and with high atom economy.
2019·8citations·Sveva Pelliccia et al.·Symmetry
Symmetry
Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds
The Ugi 5-Center-4-Component Reaction (U-5C-4CR) effectively generates diverse libraries of polycyclic (spiro) compounds by utilizing chiral cyclic amino acids, benzyl isocyanide, and cyclic ketones.
2018·9citations·L. Moni et al.·Frontiers in Chemistry
Frontiers in Chemistry