Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy- Quinazoline - 4, 6- diamine

doi:10.2991/MMECEB-15.2016.158

Paper

Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy- Quinazoline - 4, 6- diamine

Published 2016 · Yiqiang Ouyang, C. Chen, Ping Wang

UNKNOWN SJR score

0

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

N-4- (4 - chloro- 3 -trifluoromethyl -phenyl ) -7 - methoxy - quinazoline -4, 6-diamine (1) exhibited potential biological activities in medicine, 4-chloro-7-fluoro-6-nitro-quinazoline (2) is an important intermediate in compound 1. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 4-chloro-7-fluoro-6-nitro-quinazoline 2 through three steps including substitution with phenylamine, nucleophilic substitution reaction and reduction reaction. The structures were confirmed by 1 HNMR. Furthermore, the synthetic method was optimized.

Study Snapshot

A rapid synthetic method for N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy- Quinazoline-4, 6-diamine has been established, demonstrating potential biological activities in medicine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy- Quinazoline - 4, 6- diamine

Sign up to use Study Snapshot

References

Molecular designing and in silico evaluation of darunavir derivatives as anticancer agents

Darunavir analogues show potential as anticancer drugs, with potential against all cancer biomarkers and pharmacokinetic properties suitable for further development.

Novel therapies for metastatic castrate-resistant prostate cancer.

Targeting tumor stromal elements in addition to cancer epithelial cells has led to the development of novel therapies for metastatic castrate-resistant prostate cancer.

Structure-based virtual screening of Src kinase inhibitors.

Novel compound '43', identified through virtual screening, shows potential as an effective Src inhibitor candidate for further lead optimization.

Quinazoline derivatives as an multiplex inhibitor and method for the preparation thereof

Quinazoline derivatives effectively suppress tyrosine kinase-induced diseases by acting as multi-inhibitors in pharmaceutical compositions and therapeutic compositions.

Aminoquinazoline derivatives and their salts and methods of use

The invention provides useful amino-quinazoline derivatives, salts, and pharmaceutical formulations for regulating protein tyrosine kinase activity and intercellular and intracellular signaling in mammals, particularly treating hyperproliferative disorders in humans.

Citations