Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

doi:10.1016/j.bmcl.2010.07.001

Paper

Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

Published Sep 1, 2010 · F. Giraud, P. Marchand, D. Carbonnelle

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

N-aryl-3-(indol-3-yl)propanamides show promising immunosuppressive activities, with 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

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References

A Novel Indole-3-propanamide Exerts Its Immunosuppressive Activity by Inhibiting JAK3 in T Cells

AD412 shows potential as an immunosuppressive agent by inhibiting JAK3 in T cells, potentially prolonging heart allograft survival and potentially benefiting transplantation and autoimmune diseases.

Janus kinases in immune cell signaling

The Janus family kinases play a crucial role in immune cell signaling, leading to autoimmune diseases and malignancies, and their inhibition can potentially be used to control these diseases.

The JAK kinases: not just another kinase drug discovery target.

JAK kinases play a crucial role in various pathologies, making them potential drug targets for cancer and immune deficiencies.

Therapeutic targeting of Janus kinases

Targeting Janus kinases, particularly JAK3, shows promise for developing new immunosuppressive drugs for various disorders.

Effects of cyclosporine, tacrolimus and sirolimus on vascular changes related to immune response.

Sirolimus effectively prevents donor-specific antibody formation and reduces macrophages in arterial transplantation compared to tacrolimus and cyclosporine.

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