K. Mogilaiah, P. Reddy, R. Rao
Jul 1, 2003
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Influential Citations
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Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
Ethyl 1,8-naphthyridin-2-one-3-carboxylate 1 on fusion with different anilines at 200°C affords N-aryl-1,8-naphthyridin-2-one-3-carboxamides 2, which undergo smooth cyclization with POCl 3 yielding 1-arylazetidino [2,3-b][1,8]naphthyridin-2(1H)-ones 3. Compound 1 on treatment with POCl 3 yield ethyl 2-chloro-1,8-naphthyridine-3-carboxylate 4, which on reaction with aromatic acid hydrazides in methanol furnishes respective N-aroyl-N'-(3-carbethoxy-1,8-naphthyridin-2-yl) hydrazines 5. Cyclization of 5 with POCl 3 under reflux result in the formation of 1-aryl-4-carbethoxy-1,2,4-triazolo [4,3-a][1,8]naphthyridines 6. Compounds 3 and 6 have been evaluated for their antibacterial activity using streptomycin as a reference compound.