N. Lin, Yun He, H. Kopecká
Apr 10, 1995
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole ( 1 ) is a cholinergic channel activator with potent congitive and anxiolytic activities in animal models. A three-pot synthesis of enantiomerically pure ABT-418 starting from commercially available (S)-pyroglutamic acid is described. The overall yield of the synthesis is 43%. 1