Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds.

doi:10.1016/j.ejmech.2011.01.073

Paper

DOI: 10.1016/j.ejmech.2011.01.073

Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds.

Published May 1, 2011 · J. Barlow, Aengus P McHugh, Orla Woods

European journal of medicinal chemistry

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 shows promising activity as a mast cell-stabilizing and anti-allergic agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/j.ejmech.2009.09.005

A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties.

Two lead compounds, 5 and 15, show substantial mast cell stabilisation activity, potentially benefiting asthma treatment by reducing inflammation and bronchoconstriction.

2009·13citations·H. Sheridan et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/j.bmcl.2009.08.060

Diastereoisomers of 2-benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: potential anti-inflammatory agents.

Novel diastereoisomers of 2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol show significant anti-inflammatory activity in vivo and in vitro, potentially representing a new class of anti-inflammatory agents.

2009·24citations·H. Sheridan et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/j.ejmech.2008.02.009

Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds.

4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives show potential as mast cell stabilizing and anti-inflammatory compounds.

2008·19citations·J. Barlow et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1021/ja8032179

Intramolecular O-H...O hydrogen-bond-mediated reversal in the partitioning of conformationally restricted triplet 1,4-biradicals and amplification of diastereodifferentiation in their lifetimes.

Intramolecular hydrogen bonding significantly influences the lifetimes and partitioning of triplet 1,4-biradicals, affecting their cyclization and elimination behavior.

2008·23citations·J. N. Moorthy et al.·Journal of the American Chemical Society

Journal of the American Chemical Society

DOI: 10.1002/JCCS.200800126

Synthesis of 2‐[4‐(Imidazolin‐2‐Ylideneamino)Benzyl]‐Indan‐1‐Ones as Novel Potent Prostacyclin Antagonists

Novel potent prostacyclin antagonists, 2-[4-(imidazolin-2-ylideneamino)benzyl]-indan-1-ones, show potential in alleviating inflammation-induced pain and isovolumetic distention.

2008·1citation·C. Chern et al.·Journal of The Chinese Chemical Society

Journal of The Chinese Chemical Society

Citations

DOI: 10.1016/j.molstruc.2024.138722

Synthesis and conformational aspects of 2-phenoxytetralones: Experimental verification and density functional theory (DFT) calculation

2-phenoxy-1-tetralones show a remarkable conformational inversion on tetralin ring when forming (Z)-oxime on 1-position, indicating potential bioactivity.

2024·0citations·Mahsa Ansari et al.·Journal of Molecular Structure

Journal of Molecular Structure

DOI: 10.1002/ejoc.202100597

KO‐ t ‐Bu Catalyzed Thiolation of β ‐(Hetero)arylethyl Ethers via MeOH Elimination/hydrothiolation

This study presents a KO-t-Bu catalyzed thiolation of -(hetero)arylethyl ethers through MeOH elimination, yielding linear thioethers with various substrates and thiols.

2021·4citations·Masanori Shigeno et al.·European Journal of Organic Chemistry

European Journal of Organic Chemistry

DOI: 10.1021/acs.orglett.9b02309

Catalytic Amination of β-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4.

The catalytic amination of -(hetero)arylethyl ethers with amines using t-Bu-P4 allows for the transformation of electron-deficient and electron-neutral ethers into various amines, with a two-reaction pathway.

2019·13citations·Masanori Shigeno et al.·Organic letters

Organic letters

DOI: 10.1021/acs.orglett.8b03705

Domino Synthesis of Benzo-Fused β,γ-Unsaturated Ketones from Alkenylboronic Acids and N-Tosylhydrazone-Tethered Benzonitriles.

The domino reaction between alkenylboronic acids and N-tosylhydrazone-tethered benzonitriles leads to,-unsaturated indanones and tetralones, with potential for stereoselective preparation of cis-

2019·11citations·M. Plaza et al.·Organic letters

Organic letters

DOI: 10.1002/ardp.201800019

Design, synthesis, and biological evaluation of 2‐substituted‐2,3,4,9‐tetrahydrospiro‐β‐carboline‐3‐carboxylic acid derivatives as first‐in‐class mast cell stabilizers

Spiro-carboline derivatives show potential as first-in-class mast cell stabilizers, with potential applications in diseases like asthma, eczema, and allergic rhinitis.

2018·1citation·Jatinder Singh et al.·Archiv der Pharmazie

Archiv der Pharmazie