Synthesis of antiarrhythmic [phenyl‐14C]4′‐[(4‐piperidyl)carbonyl]‐methanesulfonanilides

doi:10.1002/JLCR.2580280806

Paper

Synthesis of antiarrhythmic [phenyl‐14C]4′‐[(4‐piperidyl)carbonyl]‐methanesulfonanilides

Published Aug 1, 1990 · H. Oinuma, K. Miyake, M. Yamanaka

Journal of Labelled Compounds and Radiopharmaceuticals

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Abstract

Syntheses of [phenyl-14C]4′-[[1-[2-(6-Methyl-2-pyridyl)ethyl]-4-piperidyl]carbonyl]methanesulfon-anilide dihydrochloride dihydrate (1) (14C-E-4031) and its pyridylpropyl analogue (2), that are selective class III antiarrhythmic agents, are described. A modified Michael reaction of (6), a key intermediate amine prepared from [U14C]aniline hydrochloride, with 6-methyl-2-vinylpyridine (7) and alkylation of (6) with 4-(3-chloropropyl) pyridine (8) respectively produced compounds, (1) and (2), in satisfactory yields.

Study Snapshot

The study presents a method for synthesizing selective class III antiarrhythmic agents, [phenyl-14C]4′-[(4-piperidyl)carbonyl]-methanesulfonanilides, using a modified Michael reaction and alkylation of intermediate amines

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of antiarrhythmic [phenyl‐14C]4′‐[(4‐piperidyl)carbonyl]‐methanesulfonanilides

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References

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Sudden coronary death: pharmacological interventions for the prevention of ventricular fibrillation

Pharmacological interventions targeting vulnerable electrophysiological mechanisms are crucial for preventing sudden coronary death.

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