Li Li
2003
Citations
0
Influential Citations
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Citations
Journal
Journal of Sichuan University
Abstract
R-2-hydroxy-4-phenyl ethyl butyrate is an important intermediate of an angiotension converting enzyme inhibitor. R-2-hydroxy-4-phenyl butyric acid and its ethyl ester was synthesized with DL-malic acid as starting material by a series reation, such as enzyme activity, resolution, Frieded-Crafts reaction, hydrogenolysis, esterification in general pressure. The study provided a practicable method for industrial production of this remedy.