Tomoyuki Hasegawa*, Hisashi Yamamoto
Feb 1, 2000
Citations
0
Influential Citations
55
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
(R)-2-Propyloctanoic acid has been developed as a novel therapeutic agent for Alzheimer's disease. A large-scale synthesis of this candidate was achieved by using Oppolzer's camphorsultam as a chiral auxiliary under improved conditions. It was essential for the successful synthesis of this compound to utilize a new removal method for the chiral source with a combination of tetrabutylammonium hydroxide and hydrogen peroxide. The present process afforded the desired product in high yield with high optical purity.