L. Dengke
2011
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To synthesis pazopanib hydrochloride and optimize the process.METHODS Pazopanib hydrochloride was synthesized from 3-methyl-6-nitro-1H-indazole via N-methylation,reduction,nucleophilic substitution and salification.RESULTS Chemical structure of pazopanib hydrochloride was confirmed by 1H-NMR,MS and IR.CONCLUSION The method is suitable for industry.