W. Ping
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Pazopanib hydrochloride,an antitumor agent,was synthesized from 2-ethylaniline by nitration,cyclization,methylation,reduction,substitution with 2,4-dichloropyrimidine and methylation to give 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine,which was subjected to condensation with 2-methyl-5-aminobenzene sulfonamide and then salt formation with an overall yield of about 28%.