Li Shu-xin
2013
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Fine Chemical Intermediates
Abstract
Pazopanib hydrochloride,an antitumor agent,was synthesized in overall yield of 34.56% via reaction of 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine,which was synthesized in several steps starting from 2-ethylaniline,with 2-methyl-5-aminobenzene sulfonamide.The structure was confirmed by 1H NMR and MS.