Song Dan-qing
2005
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Journal
Chinese New Drugs Journal
Abstract
Objective:To synthesize pioglitazone hydrochloride.Methods: The target compound was synthesized from 2-(5-ethyl-2-pyridyl)-ethanol as a starting material via six steps including condensation,reduction,diazotization,cyclization,hydrolysis and saltilization.Results: The structure of the target compound was confirmed by MS,()~1H-NMR,IR and X-ray crystal analysis.The total yield of pioglitazone hydrochloride was 12.8%.Conclusion: This cost-saving and simplified method can be used in the industrial manufacture.