Y. Hidai, T. Kan, T. Fukuyama
Jun 18, 1999
Citations
0
Influential Citations
42
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The total synthesis of HO-416b ( 1 ) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. Starting with monosulfonylated diamines 2 and 3 , three CN bonds were constructed via alkylation of sulfonamides with alkyl halides. Removal of the Ns groups while the substrate was attached to a novel solid support enabled the efficient isolation of pure 1 .