Han Lijun
2010
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Journal
Marine Sciences
Abstract
Methyl 3-bromo-2-(2′,3′-dibromo-4′,5′-dimethoxybenzoyl)-4,5-dimethoxybenzoate 9 was synthesized employing bromination,reduction,oxidation,and Friedel-Crafts reaction,with an overall yield of 19.6%.The inhibitory activity against protein tyrosine phosphatase 1B(PTP1B) of compound 9 was tested by a colorimetric assay.It was found that compound 9 displayed a good inhibitory activity against PTP1B(55.84% inhibition at 20 mg/L).