SYNTHESIS OF PYRIDAZINE DERIVATIVES. IX. NITRATION OF 3,4-DIMETHYLPYRIDAZINE N-OXIDE DERIVATIVES.

doi:10.1248/CPB.11.726

Paper

SYNTHESIS OF PYRIDAZINE DERIVATIVES. IX. NITRATION OF 3,4-DIMETHYLPYRIDAZINE N-OXIDE DERIVATIVES.

Published Jun 25, 1963 · T. Nakagome

Chemical & pharmaceutical bulletin

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6

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0

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Abstract

Nitration of 3, 4-dimethyl (Ia), 6-chloro-3, 4-dimethyl (Ib), 6-methoxy-3, 4-dimethylpyridazine 2-oxide (Ic), 3, 4-dimethyl (Id) and 3-methylpyridazine 1-oxide (Ie) was examined and it was proved that Ia, Ib, Ic and Ie afforded γ-nitropyridazine N-oxides (IIa∼IIe), whereas Id in which γ-position was substituted gave α-nitro N-oxide (IId). All of these nitro derivatives were derived to aminopyridazines (IIIa∼IIIe) by catalytic reduction over Raney-nickel in methanol or over palladium-charcoal in dilute hydrochloric acid. Ultraviolet spectra of several aminopyridazines are also given.

Study Snapshot

Nitration of 3,4-dimethylpyridazine N-oxide derivatives leads to -nitropyridazine N-oxides, which can be further converted to aminopyridazines by catalytic reduction over Raney-nickel in methanol

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

SYNTHESIS OF PYRIDAZINE DERIVATIVES. IX. NITRATION OF 3,4-DIMETHYLPYRIDAZINE N-OXIDE DERIVATIVES.

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References

Citations

Pyrrolopyridazines. II. Synthesis of the novel pyrrolo[3,2-c]pyridazine ring system †

The novel pyrrolo[3,2-c]pyridazine ring system was successfully synthesized in good yields by cyclizing 4-ethoxymethyl-eneamino-3-methylpyridazine 1-oxide (3) and 3-chloro-5-(-e

Reaktion von γ‐Halogen‐α‐cyancrotonsäurenitrilen mit Aminen

Substituted -Halogen--cyancrotonsaurenitrile 1 reacts with primary amines and ammonia to form substituted 2-amino-3-cyanpyrroles, with arylamines providing 1-arylpyrroles and alkylamines producing