R. Bhutani, Abhishek Sharma, Akanksha Gupta
Mar 2, 2023
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Quality indicators
Journal
Combinatorial chemistry & high throughput screening
Abstract
BACKGROUND The triazole analogues are molecules of immense attraction because of their wide pharmacological applications. METHODS Present research deals with the synthesis of triazole-2-thione analogues and their QSAR study. The synthesized analogs are also evaluated for their antimicrobial, anti-inflammatory, and antioxidant effect. RESULTS It was revealed that the benzamide analogues (3a, 3d) and triazolidine analogue (4b) were found to be most active against P. aeruginosa and E. coli with pMIC values of 1.69, 1.69 and 1.72, respectively. The antioxidant study of the derivatives showed that 4b was the most active antioxidant with 79% protein denaturation inhibition. The highest anti-inflammatory activity was shown by 3f, 4a and 4f. CONCLUSION This study provides certain potent leads for further development of more potential anti-inflammatory, antioxidant and antimicrobial agents.