Xu Wei-yun
2010
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Journal
Journal of Wuhan Institute of Technology
Abstract
The cheap ferrocene was used as the starting material to synthesize(R)-N,N-Dimethyl-1-ferrocenylethylamine by F-C acylation,reduction,esterification,amination and resolution.(S)-1-N,N-dimethyl-[2-(R)-(diphenylphosphino)ferrocenyl]ethylamine was obtained by high enantioselectve reaction of(R)-N,N-Dimethyl-1-ferrocenylethylamine and Ph2Cl,then the target compound(R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyl-di-3,5-xylylphosphine was manufacturated by substitution of Xyl2PH and(S)-1-N,N-dimethyl-[2-(R)-(diphenylphosphino)ferrocenyl]ethylamine.The total yield was 14.6% and its purity was 97%.The structure was confirmed by 1H-NMR,13C-NMR,31P-NMR.The results showed that the route is feasible,the operation is simple,safe,and yield of the product is higher.The synthesis route could meet the demands of large industrial production.