Synthesis of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile via a one-pot, three-component reaction

doi:10.1016/J.TETLET.2010.03.109

Paper

Synthesis of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile via a one-pot, three-component reaction

Published Jun 2, 2010 · Abbas Rahmati

Tetrahedron Letters

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Abstract

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A one-pot, three-component reaction using aldehyde, 3-amino-5-methylpyrazole, and ethyl cyanoacetate in ethanol produces high yields of 4-aryl-3-methyl-6-oxo-2H-pyrazolo[3,4-b

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of 4-aryl-3-methyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile via a one-pot, three-component reaction

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References

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

New pyridine and pyrazolo[1,5-a]pyrimidine derivatives show potent anti-tumor cytotoxic activity in vitro using various human cancer cell lines.

Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.

Pyazolo[1,5-a]pyrimidine-3-carboxylates show potential as B-Raf kinase inhibitors, potentially benefiting cancer treatment for melanomas, colorectal cancer, and other Ras-related diseases.

Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.

Novel pyrazolo[1,5-a]pyrimidines with optimized phenyl amide moiety at C-7 position effectively kill p21-deficient cancer cells, potentially targeting tumor cells while sparing normal cells.

Human cytochrome P450 1A2 involvement in the formation of reactive metabolites from a species-specific hepatotoxic pyrazolopyrimidine derivative, 5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidine.

Human liver microsomal P450 1A2 preferentially metabolizes OT-7100 to a human-specific reactive metabolite, potentially contributing to its hepatotoxicity.

Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes.

Multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes can be tuned to produce pyrazoloquinolinones, isomeric pyrazoloquinazolinones, and pyrazoloquinazolinones using

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