D. Black, G. Edwards, R. H. Evans
Mar 24, 2000
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron
Abstract
Abstract Some C5 mono- and diester-substituted 1-pyrroline-1-oxides have been prepared via reductive cyclisation of the corresponding γ-nitro carbonyl compounds. Ethyl 2-phenyl-1-pyrroline-1-oxide-5-carboxylate 5c was regioselectively alkylated at C5. Acylation of this molecule occurs exclusively on the nitrone oxygen and leads to C3 substituted pyrrolines as the result of a hetero-Cope rearrangement.