N. De Rycke, G. Berionni, F. Couty
Feb 4, 2011
Citations
0
Influential Citations
47
Citations
Journal
Organic letters
Abstract
3,4,5-Triamino-substituted pyridines are avid for electrophiles but are still willing to give them back. In these compounds three amino groups conjoin their forces into the heterocyclic nitrogen, making it a powerful Lewis base. A short and efficient synthesis is described, and the origin of its unique activity in nucleophilic organocatalysis is rationalized by kinetics and thermodynamic quantifications.