Synthesis and reactivity of 2,6-diamino-4-methyl-3-pyridinecarbonitrile

doi:10.1002/JHET.5570320351

Paper

Synthesis and reactivity of 2,6-diamino-4-methyl-3-pyridinecarbonitrile

Published May 1, 1995 · A. Katritzky, S. Rachwał, Terrance P. Smith

Journal of Heterocyclic Chemistry

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5

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0

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Abstract

2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2,6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2,6-diamino derivatives. The last reacts with benzene-sulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.

Study Snapshot

2,6-diamino-4-methyl-3-pyridinecarbonitrile is a versatile and reactivity-enhancing reagent for synthesising various derivatives and preparing tris-sulfonyl compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and reactivity of 2,6-diamino-4-methyl-3-pyridinecarbonitrile

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References

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Medicine in China.

Acute ischaemic colitis can be effectively treated with steroids, antibiotics, and fluid replacement, and thyroxine can return the patient's appearance and bowel habit to normal.

Citations

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Substituted pyridine, pyrido[3,2c]pyridazine, and pyrido[3,2c]pyridazino[2′,3′-a]quinazoline derivatives show promising molluscicidal activity

Further studies on the reaction of ethyl benzoylacetate with malononitrile: synthesis of some novel pyridine and pyridazine derivatives

Ethyl benzoylacetate with malononitrile can produce novel pyridine and pyridazine derivatives, with some azo derivatives of nicotinonitriles and 2-aminopyran.