The synthesis and molecular recognition study of β-cyclodextrin derivatives modified by spiro[2H-benzopyran-2,2′-indoline]

doi:10.1007/S10847-010-9743-2

Paper

The synthesis and molecular recognition study of β-cyclodextrin derivatives modified by spiro[2H-benzopyran-2,2′-indoline]

Published Feb 5, 2010 · Yi Huang, Jincai Guo

Journal of Inclusion Phenomena and Macrocyclic Chemistry

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Abstract

In this study, we adopted the condensation reaction between the aldehyde group in spiro[2H-benzopyran-2,2′-indoline] and the ethylene diamine in β-cyclodextrins to synthesize 1,3,3-trimethyl-6′-mono-(6-deoxy-ethylenediimine-β-cyclodextrin)-spiro[2H-benzopyran-2,2′-indoline] (β-CD-SPBI). The structure of the target compound was characterized by elemental analysis, NMR and IR spectroscopy. The UV–Vis and fluorescence spectroscopy were investigated in different solvents. The preliminary study of its molecular recognition was also conducted. The results indicated that β-CD-SPBI existed as two structural isomers, both of which showed significant fluorescent characteristics and β-CD-SPBI could showed the capacity of dual molecular recognition of a drug, ribavirin.

Study Snapshot

-CD-SPBI, a -cyclodextrin derivative modified by spiro[2H-benzopyran-2,2′-indoline], shows potential for dual molecular recognition of ribavirin, offering potential for drug delivery and pharmacological applications

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The synthesis and molecular recognition study of β-cyclodextrin derivatives modified by spiro[2H-benzopyran-2,2′-indoline]

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References

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Citations

Spiropyran, chromene or spirooxazine ligands: Insights into mutual relations between complexing and photochromic properties

Spiropyran, spirooxazine, and chromene molecules can be used to create photoswitchable molecular receptors that can coordinate metal ions, amino acids, and DNA molecules, with changes in optical characteristics.