Meng‐Yang Chang, Pei-Pei Sun, Shui-Tein Chen
Aug 1, 2003
Citations
0
Influential Citations
6
Citations
Journal
ChemInform
Abstract
tract - A facile synthesis of rolipram via stepwise [3+2] annulation and desulfonated hydrolysis was reported. Base-induced coupling/cyclization reactions of α-sulfonylacetamide with (Z)-2-bromoacrylic ester yielded threecontiguous centers on the pyroglutamate system with trans-trans orientation as the one-pot key step.