Li Qian
2007
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Ropinirole hydrochloride was synthesized from 2-methyl-3-nitrophenylacetic acid by chlorination, amidation, and reduction to give N,N-dipropyl-2-methyl-3-nitrophenethylamine, which was subjected to condensation with oxalic acid diethyl ester, hydrolysis and reduction to give 2-nitro-6-[2-(dipropylamino)ethyl]phenylacetic acid followed by reduction, cyclization and salt formation with an overall yield of about 36%.