A. A. Santilli, R. Morris
Sep 1, 1979
Citations
0
Influential Citations
14
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Several new 3-arylsulfonylmethyl-1,2,4-oxadiazole-5-carboxylic acid derivatives have been synthesized. A typical example, 3-[(4-chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid ethyl ester (2c), was prepared from the reaction of 2-(4-chlorophenylsulfonyl)acetamide oxime (1c) with ethyl oxalyl chloride. The hydrazide derivative (3f) showed antihypertensive activity in rats. Various structural modifications to improve activity are discussed.