Li Qiang, Zhu Jinlin, Huang Wei
2012
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Solifenacin succinate was synthesized from phenethylamine by acylation,Bischler-Napieralski cyclization,reduction by NaBH4 and resolution to afford(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline(6),which was subjected to condensation,ester exchange and then salification with an overall yield of about 21%.