SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-(1,2,4)TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY

doi:10.18036/BTDC.71621

Paper

SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-(1,2,4)TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY

Published Jul 29, 2011 · Ahmet Özdemir, Z. Kaplancıklı, G. Turan-Zitouni

Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology

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Abstract

The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide derivatives were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides with appropriate 4H-[1,2,4]triazol-2-thione. The chemical structures of the compounds were elucidated by elemental analyses, IR, 1 H-NMR, 13 C-NMR and FAB + -MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus ( ATCC 6538) , Pseudomonas aeruginosa ( ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) ( clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organism.

In Vitro Study

Study Snapshot

N-(benzothiazolyl-2-yl)-2-(4H-(1,2,4]triazol-3-ylsulfanyl)acetamide derivatives show inactive antimicrobial activities against tested organisms.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-(1,2,4)TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY

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References

Synthesis and antimicrobial activity of new 1,2,4-triazole-3-thiol metronidazole derivatives

New 1,2,4-triazole-3-thiol metronidazole derivatives show promising antiparasitic, antibacterial, and antifungal properties against Entamoeba histolytica and Giardia intestinalis.

Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities.

The synthesized 1,2,4-triazoles show good or moderate antimicrobial activity, except for compounds 2 and 9b, which show no activity.

Metabolically stabilized benzothiazoles for imaging of amyloid plaques.

Metabolically stabilized benzothiazoles with fluorine substitutions show potential for in vivo imaging of amyloid plaques, with two lead compounds identified with improved physicochemical characteristics.

Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials.

Compounds 2b, 2c, 2d, 3b, 3c, and 3d show significant inhibition against various strains of bacteria compared to standard drugs.

Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.

Fluorinated 2-(4-aminophenyl)benzothiazoles show potent cytotoxic effects against sensitive human breast cancer cell lines, with the most potent broad spectrum agent being 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (10h).

Reference method for broth dilution antifungal susceptibility testing of yeasts : Approved standard

The third edition of CLSI document M27-A3 provides a standard for testing antifungal agent susceptibility to yeasts, including Candida spp. and Cryptococcus neoformans, in invasive fungal infections.

Citations

Synthesis, Characterization and DFT Calculations of 1,4-diphenyl-3-(p-nitrophenylamino)-1,2,4-triazolium Hydroxide Inner Salt (Nitronitron) by 1 H NMR, FT-IR, UV/Vis and HOMO-LUMO Analysis

The novel compound, Nitonitron, was synthesized and characterized using 1H NMR, FT-IR, UV/Vis, and HOMO-LUMO analysis, with good agreement between experimental and calculated results.