M. T. Aal
Jan 1, 2002
Citations
0
Influential Citations
13
Citations
Journal
Synthetic Communications
Abstract
ABSTRACT Ethyl4-(3,4-dimethoxyphenyl)-2-methyl-3-oxobutanoate (1) is synthesized in a high yield from 3,4-dimethoxybenzylcyanide and 2-bromopropionate. Condensation of (1) with thiourea in EtOH/NaOEt afforded the thiopyrimidine (2). Alkylation of (2) with halo compounds gave new thio-analogues of DABO's (3–7), whereas desulfurization of (2) by chloroacetic acid afforded the uracil (3). Reaction of (3) with chloromethyl ethers yielded new analogues of HEPT (10a,b).