Yang-Heon Song
2007
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Journal
Journal of Guizhou University
Abstract
2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)pyridine-3-carboxamide was synthesized by the reaction of 2-chloro-3-amin0-4-methylpyridine(CAPIC) and 2-chloropyridine-3-carboxylic acid,and the optimal reaction conditions were investigated,the reactants molar ratio of [2-chloro-3-amino-4-methylpyridine∶2-chlorooctanic acid∶POCl3∶ Et3N] was 1∶1∶1∶1.1,the reaction temperature 81 ?C,and adding time of 3.5 h provided the best result.The yield and purity of the target product was 90.3% and 99.5%,respectively.