SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE

Paper

SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE

Published Jul 1, 2016 · E. Ramadan

International Journal of Pharmacy and Pharmaceutical Sciences

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Abstract

Objective: A series of substituted 2-hydrazono-2(3 H )-thiazole derivatives were synthesized from 4-(3-chlorophenyl)-3-thiosemicarbazide and evaluated in vitro for antimicrobial activity against Escherichia coli , Candida albicans , Pseudomonas aeruginosa , Bacillus subtilis and Staphyllococcus aureus. Methods: 4-(3-Chlorophenyl)-3-thiosemicarbazones were synthesized and allowed to react with 2,4′-dibromoacetophenone to give 2-hydrazono-2(3 H )-thiazoles in excellent yields. The synthesized compounds were characterized by spectroscopic methods as well as elemental analyses. They were screened for their antimicrobial activity by using the agar diffusion method. Results: The antimicrobial data suggested that all compounds showed significant activity against E. coli and C. albicans compared to the standard drug. Only 7b and 7d exhibited moderate activity against P. aeruginosa . Conclusion: Compounds bearing a substituted phenyl or indolyl group at the hydrazone moiety have considerable antimicrobial activity than those with a cycloalkyl group. Keywords: 2,3-Dihydrothiazole, 4-(3-Chlorophenyl)-3-thiosemicarbazide, Antimicrobial activity

In Vitro Study

Study Snapshot

Substituted phenyl or indolyl groups at the hydrazone moiety in 2-hydrazono-2(3H)-thiazole derivatives show significant antimicrobial activity against Escherichia coli and Candida albicans, with moderate activity against Pseu

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE

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References

Citations

Synthesis and Biological Evaluation of New 3-Phenylthiazolidin-4-One and 3-Phenylthiazole Derivatives as Antimicrobial Agents

New 3-phenylthiazolidin-4-one and 3-phenylthiazole derivatives show excellent antimicrobial activity, with compounds 4d, 6a, 6d, and 6f showing over 90% activity against Gram-positive and Gram-negative bacteria and fungi.

Synthesis and mass spectrometry of some arylidene-hydrazinyl-thiazolines and their 2-arylidene-N-(3-chlorophenyl)hydrazinecarbothioamide precursors

This study successfully synthesized 2-arylidene-N-(3-chlorophenyl)hydrazinecarbothioamides (3a-e) and their precursors, resulting in 2-(arylidenehydrazono)-4-(4-bromophenyl)

ISOLATION OF ANTIBACTERIAL PROTEIN/PEPTIDE FROM FICUS GLOMERATA LEAF

Ficus glomerata leaf contains a novel protein with broad spectrum antibacterial activity, which can be used for plant protection and the development of novel therapeutic agents.