H. Azeez, S. Hamad
Apr 27, 2017
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Journal
ZANCO Journal of Pure and Applied Sciences
Abstract
4-n-propoxy benzoic acid (A) was prepared by alkylation of 4-hydroxy benzoic acid with n-propyl bromide, on the basis of Williamson synthesis of ethers in the presence of Potassium hydroxide using absolute ethanol- water (10:1) . Compound (A) was in turn converted to 2-amino 5- (4-n -propoxyphenyl )- [1,3,4]-thiadiazole (A 1 ) by the reaction with thiosemicarbazide in the presence of phosphorus oxychloride. Some new aromatic Schiff bases ( substituted benzylidene ) - [5- (4-n-propoxy-phenyl)-[1, 3, 4]-thiadiazol- 2- yl]-amine (B (1 – 8 ) ) were synthesized by condensation of equimolar amounts of compound ( A 1 ) and substituted benzaldehydes in absolute ethanol using glacial acetic acid as a catalyst. The structure of products were confirmed by (I.R, 1 H-NMR, 13 C- NMR and DEPT - 135) spectra .