Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

doi:10.1134/S1070363220120233

Paper

Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

Published Dec 1, 2020 · N. Abbas, G. Shabir, A. Saeed

Russian Journal of General Chemistry

Q4 SJR score

2

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The present study is devoted to the synthesis of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its transition metal complexes. Synthesis of the ligand has been achieved by the condensation reaction of N,N-diethylsalicylaldehyde with 4-chloro-2-aminophenol in acidic medium. Metals complexes of the ligand with different transition metal ions [M2+= Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and Pd(II)] have been accumulated in alcoholic media and characterized by spectroscopic methods. UV-Vis analysis of the complexes indicates the ligand coordination to the metal ions via both OH groups and the azomethine nitrogen atom, acting as a tridentate ligand. Anticancer tests of selected complexes demonstrate moderate in vitro activity of Cu(II) complex against HeLa cell line.

Study Snapshot

4-chloro-2-[5-(diethylamino)-2-hydroxybenzylidene]amino-phenol and its transition metal complexes show moderate in vitro anticancer activity against HeLa cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

Sign up to use Study Snapshot

References

Chromium (III) complexes of azo dye ligands: Synthesis, characterization, DNA binding and application studies

Chromium (III) complexes of azo dye ligands show moderate to high light fastness and perspiration fastness, binding to DNA through intercalation mode and showing potential for use in leather applications.

Synthesis, characterization, solvatochromism and biological properties of 2,2'-((1E,1'E)-((1,2,5-oxadiazole-3,4-diyl)bis (azanylylidene))bis(methan-ylylidene))bis(4-(phenyldiazenyl)phenol).

The synthesized compounds show moderate antioxidant activity and varied antibacterial activity against B. cereus and S. aureus strains.

Spectroscopic and solvatochromism studies along with antioxidant and antibacterial activities investigation of 2-((2-mercaptophenylimino)methyl)-4-(phenyldiazenyl)phenol.

Compound 2b shows antibacterial activity against Staphylococcus aureus and Bacillus cereus, while also showing the best antioxidant properties among the tested compounds.

Characterization, molecular modeling and antimicrobial activity of metal complexes of tridentate Schiff base derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol.

Metal complexes synthesized from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol show antimicrobial activity against sensitive organisms Staphylococcus aureus, Proteus vulgaris, and

Synthesis and characterisation of two double EE azido and thiocyanato bridged dimeric Cu(II) complexes with tridentate Schiff bases as blocking ligands

Two new double end-to-end azido and thiocyanato bridged copper(II) dimers with tridentate Schiff bases as blocking ligands have been synthesized and characterized, showing octahedral geometry in one and square-pyramidal in the other

Citations

Nitrosopyrazolone Metal Complexes, Synthesis, Characterization and Biological Studies

Nitrosopyrazolone metal complexes show promising results in reducing Hep-G2 cancer cell growth, with potential applications in cancer therapy.