E. Paronikyan, S. Dashyan, H. Panosyan
Aug 1, 2018
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Chemistry of Heterocyclic Compounds
Abstract
A new and effective method was developed for obtaining diamino derivatives of pyrano[3,4-c]pyridines and 5,6,7,8-tetrahydro-isoquinolines from 3-cyanopyridin-2(1H)-ones by Smiles rearrangement of the respective oxyacetamides. The structures of the synthesized compounds were studied by NMR spectroscopy and X-ray diffraction analysis. The results of X-ray diffraction studies revealed the presence of intermolecular hydrogen bonds in 6-(benzylamino)-3,3-dimethyl-8-(pyrrolidin-1-yl)-3,4-dihydro-1H-pyrano-[3,4-c]pyridine-5-carbonitrile. The obtained compounds were also tested for antimicrobial activity.