D. Fenton, R. Moody, U. Casellato
Nov 1, 1985
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0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The synthesis and the x-ray structure of 5-hydroxy-2-methyl-(2-pyridinyl)hexahydro-1,3-pyrimidine are reported. The compound was prepared by reaction of 2-acetylpyridine and 1,3-diamino-2-hydroxypropane in a 2:1 molar ratio. The colourless crystals are monoclinic, space group P21/c with cell parameters, a = 10.385(5), b = 11.171(5), c = 17.415(6)A, β = 93.05(37)° for Z = 8. The asymmetric unit of the structure is composed of two independent molecules of the compound which are in the chair form and adopt the same conformation with equatorial -OH and -CH3 groups and axial pyridine substituents. The packing of the molecule seems to be controlled by two independent hydrogen-bonding sequences.