Paper

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.

Published Oct 20, 2003 · Zhiqian Guo, Yongsheng Chen, Dongpei Wu

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Thieno[2,3-d]pyrimidine-2,4-dione derivatives show potential as potent human GnRH receptor antagonists for treating reproductive diseases, with a binding affinity of 0.4 nM.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.

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