N. Lin, Yun He, J. David
Oct 20, 1994
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0
Influential Citations
11
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Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
3′ and 5′-substituted pyrrolidine analogs of the potent cholinergic channel activator (ChCA), 3-methyl-5-(2(S)-pyrrolidinyl)-isoxazole (ABT 418), 1, were synthesized and tested in vitro for cholinergic channel receptor binding activity. Since the primary metabolism of 1 is oxidation at the C5′ position, the effect of methyl substitution on the in vitro rate of metabolism was investigated.