Paper
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production.
Published Apr 21, 2005 · J. F. Gerster, K. Lindstrom, Richard L. Miller
Journal of medicinal chemistry
95
Citations
1
Influential Citations
Abstract
1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.
Highly Cited1H-imidazo[4,5-c]quinolines show antiviral activity in guinea pig herpes simplex virus-2 models due to their ability to induce interferon production, leading to the discovery of imiquimod for treating genital warts, actinic keratosis
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