Synthesis and tautomeric studies of enamines from 1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one

doi:10.1590/S0103-50532005000200009

Paper

Synthesis and tautomeric studies of enamines from 1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one

Published Apr 1, 2005 · J. Belmar, F. R. Pérez, J. Alderete

Journal of the Brazilian Chemical Society

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Abstract

1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one was acylated with acid chlorides. Condensation of acyl derivatives with primary amines afforded enamines. According to the 1H and 13C NMR data, the acyl derivatives have mainly a 4-acylpyrazol-5-ol structure with intramolecular hydrogen bond, and the 4-aminomethylene derivatives exist predominantly in the enamine form stabilized by the same type of interaction.

Study Snapshot

Enamines from 1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one can be synthesized with primary amines, resulting in mainly 4-acylpyrazol-5-ol structures with intramolecular hydrogen bond stabilization.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and tautomeric studies of enamines from 1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one

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References

Vogel's Textbook of Practical Organic Chemistry

Vogel's Textbook of Practical Organic Chemistry covers organic synthesis, experimental techniques, spectroscopic methods, solvents and reagents, aliphatic, aromatic, alicyclic, and heterocyclic compounds, and investigations and characterisations of organic compounds.

Comprehensive Heterocyclic Chemistry IV

CHEC III provides a comprehensive overview of heterocyclic chemistry, covering three- and four-membered heterocycles, their fused systems, and their fused derivatives.

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