Pseudo-three-component synthesis of substituted 1,2,4-triazolo[1,5-a]pyridines

doi:10.1007/s00706-019-02522-3

Paper

Pseudo-three-component synthesis of substituted 1,2,4-triazolo[1,5-a]pyridines

Published Dec 2, 2019 · Maryam Shokoohian, N. Hazeri, M. Maghsoodlou

Monatshefte für Chemie - Chemical Monthly

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Abstract

AbstractHeterocyclic 1,2,4-triazoles and their derivatives, such as triazolopyridines, have been used as leading components for the synthesis of numerous heterocyclic compounds; and because of their various biological activities, they have a distinct location in pharmaceutical and medicinal chemistry. In this article, we demonstrate a new way of synthesizing 1,2,4-triazolo[1,5-a]pyridine derivatives, as a one-pot pseudo-three-component reaction, via the reaction of pyridine-2-(1H)-one derivatives and 1,4-cyclohexadione in the adjacency of acetic acid both as solvent and an inexpensive and green catalyst at 50 °C. The desired products were synthesized in good yields, and the chemical structure of the synthesized compounds was recognized using ^1H and ^13C NMR spectra, FT-IR, melting point, mass spectroscopy, and elementary analysis.Graphic abstract

Study Snapshot

This study presents a new one-pot pseudo-three-component reaction for synthesizing 1,2,4-triazolo[1,5-a]pyridine derivatives using pyridine-2-(1H)-one derivatives and 1,4-cyclohexadione in acetic acid

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Pseudo-three-component synthesis of substituted 1,2,4-triazolo[1,5-a]pyridines

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