Dong Zhuo
2009
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Journal
Journal of Guangdong Pharmaceutical College
Abstract
Objective To optimize the synthetic route of suplatast tosilate to make it suitable for industrial production.Methods Epichlorohydrin was used as starting material and adopted hydrocarbylation and cyclization by one-pot method,followed with re-hydrocarbylation,catalytic hydrogenation,acylation,and salt formation to afford suplatast tosilate.Results The target compound was synthesized,with its purity more than 99 % and the total yield of 37.2 %.The structure of the product was elucidated by MS,1H-NMR,IR and elemental analysis.Conclusion Compared with the synthesis route that had been reported in the literature,the synthesis route in this study was optimized by exploration of optimization of the Molar ratio of raw materials,shortening of the reaction time,and simplification of synthesis route.