Y. Hengbo
2012
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Journal
Chemical Industry and Engineering Progress
Abstract
Diethyl thiodiglycolate was efficiently synthesized via the nucleophilic substitution of ethyl chloroacetate with Na2S.3H2O.The effects of molar ratio of Na2S·3H2O to ethyl chloroacetate,solvent and reaction temperature on the reaction rate and product yield were investigated.The maximum yield of diethyl thiodiglycolate reached 81.3% with a purity of 99% when the reaction was carried out with a molar ratio of Na2S·3H2O to ethyl chloroacetate of 0.75∶1 in 250 mL cyclohexane under reflux at 81 ℃ for 4 h.And the recovery rate of cyclohexane is more than 80%.