Fang Qiao-yun
2012
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Journal
Drugs and Clinic
Abstract
Objective To optimize the synthesis technology of ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino] benzoate.Methods Using ethyl 2-[(2'-cyanobiphenyl-4-yl) methylamino]-3-nitrobenzoate as starting material,hydrazine hydrate as reducingagent,and Pb/C as catalyst,ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino] benzoate was obtained.Results Under theoptimum conditions:molar ratio of raw material-reducing agent was 1.92:1,the quantity of catalyst Pb/C was 1.2 g,and at 75 ℃ for 2h,the yield reached 92.0%.Conclusion The synthesis technology of ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino]benzoate is stable,simple,high yield,and could be applied to industry production.