H. Jia
2001
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0
Influential Citations
1
Citations
Journal
Journal of China Pharmaceutical University
Abstract
AIM: To develop a modification of the general route for the synthesis of terbinafine. METHODS: Compound (1) was synthesized from 1 bromo 6,6 dimethyl 2 hepten 4 yne(6) by reaction with N methyl 1 naphthalenemethanamine. Compound 5 was prepared from tert butylacetylene(4) through Grignard reaction with acrolein. RESULTS: The title compound was synthesized. The structure was confirmed by IR, \+1HNMR, MS and elemental analysis data.CONCLUSION: Some improvements for the synthesis of compounds 4,5 and 7 were made.